Pulmonary vascular disease & thromboembolism
Impact of Time to Catheter-Based Therapy on Outcomes in Acute Pulmonary Embolism
Main finding · Composite of 30-day mortality, resuscitated cardiac arrest, hemodynamic instability, and 90-day readmissionResult — go to the resultHazard ratio 0.13 95% CI 0.03–0.58Authors' conclusion
Early CBT was associated with improved clinical outcomes in patients with acute intermediate-risk PE. The composite PE shock score may help identify patients who will benefit from early CBT. Further prospective studies are needed to validate these findings.
Study context
- Population
- Patients with acute intermediate-risk pulmonary embolism (PE) treated with catheter-based therapies (CBTs), January 2020 to January 2024patients included
- Participants
- 133 patients
- Exposure
- Early versus delayed catheter-based therapies
- Outcome
- Composite of:
- 30-day mortality
- Resuscitated cardiac arrest
- Hemodynamic instability
- 90-day readmission
Methodological details2 academic centers, inverse probability of treatment weighting
- 2 academic centers
- Inverse probability of treatment weighting
Main finding
As reported in the abstract
Hazard ratio
0.13
95% CI 0.03–0.58
P = 0.007
By group
- Patients who experienced the primary composite outcome
- 16 patients (12% of patients)
Observational data: associations, not effects.
Secondary outcomes
Median time to intervention
Secondary composite of 30-day mortality, resuscitated cardiac arrest, and hemodynamic instability
Intensive care unit length of stay
Hospital length of stay
- Median time to intervention: P <0.001
- Secondary composite of 30-day mortality, resuscitated cardiac arrest, and hemodynamic instability: log-rank P =0.02
- Intensive care unit length of stay: P =0.01
- Hospital length of stay: P =0.046
Primary composite outcome by timing of CBT and composite PE shock score (high ≥3; low <3)
- Of the 16 with the primary composite outcome, high composite PE shock score and delayed intervention
- 14/16 (87.5%)
- All 16 patients who experienced the primary composite outcome had a high composite PE shock score
Original publication
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