Arrhythmias & electrophysiology
Impact of treatment adherence on the effectiveness and safety of oral anticoagulants in patients with atrial fibrillation: a retrospective cohort study
Authors' conclusion
The benefits of OAC adherence in NVAF patients for ischaemic stroke prevention exceeding the risk of bleeding are shown more clearly in terms of absolute risk.
Study context
- Population
- Patients with non-valvular AF, National Health Insurance Database of Korea, January 2010 to December 2018
- Participants
- 84,227 patients
- Exposure
- OAC adherent vs non-adherent
- Adherentn = 50,178
- Non-adherentn = 34,049reference
- Outcome
- Incidence of ischaemic stroke, major bleeding and death
Main finding
Ischaemic stroke
Risk difference
2.08%
By group
As reported in the abstract
Observational data: associations, not effects.
Safety
| Outcome | Adherent | Non-adherent | Risk difference |
|---|---|---|---|
| Major bleedingIncreased risk with adherence; NNH 115 | 4.49% (95% CI 4.11–4.85%) | 3.61% (95% CI 3.16–4.06%) | 0.87% |
Original publication
Impact of treatment adherence on the effectiveness and safety of oral anticoagulants in patients with atrial fibrillation: a retrospective cohort study. Eur Heart J Qual Care Clin Outcomes. Published 9 May 2022. doi:10.
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