Arrhythmias & electrophysiology
Risk of incident genitourinary cancer following hematuria in patients with atrial fibrillation receiving oral anticoagulants
Main finding · Incident GU cancer after hematuriaResult — go to the resultOdds ratio 1.1169Authors' conclusion
GU malignancy occurs in approximately 4% of anticoagulated patients with AF experiencing hematuria.
Study context
- Population
- Patients with atrial fibrillation (AF) receiving oral anticoagulants (OACs), Taiwan National Health Insurance Research Database; Genitourinary (GU) cancer analysis in those with hematuria without prior GU malignancy18,509 with hematuria
- Participants
- 192,728 patients
- Exposure
- NOACs vs warfarin
- NOACsn = 117,187
- Warfarinn = 75,541reference
- Outcome
- Risk of hematuria and incident GU cancer after hematuria
- Follow-up
- 1 year after hematuria (GU cancer)
Methodological detailsnationwide database
- Nationwide database
Main finding
Incident GU cancer after hematuria · within 1 year after hematuria
Odds ratio
1.1169
P = 0.041
By group
As reported in the abstract
- Patients diagnosed with incident GU cancer, overall
- 738 (3.99%)
Observational data: associations, not effects.
Further findings
Factors associated with GU cancer diagnosis
- Age ≥75 years, OR
- 1.486, P < .0001
- Male gender, OR
- 2.342, P < .0001
- Abnormal renal function, OR
- 1.319, P = .0015
Safety
Per year
| Outcome | Warfarin | NOACs | aHR | P value |
|---|---|---|---|---|
| Mild hematuria | 1.71% | 2.29% | 1.107 | P < 0.0001 |
| Moderate hematuria | 0.62% | 0.84% | 1.075 | P = 0.0189 |
| Severe hematuria | 0.17% | 0.15% | 0.630 | P < 0.0001 |
Original publication
Risk of incident genitourinary cancer following hematuria in patients with atrial fibrillation receiving oral anticoagulants. Heart Rhythm. Published 28 November 2024. doi:10.
Summarised from the published abstract; every number is checked against it