Valvular & structural heart disease
Mid-Term Experience With 1,196 Ozaki Procedures
Authors' conclusion
The Ozaki procedure creates a good aortic valve with stable low gradients and left ventricular reverse remodeling. A low but increasing rate of regurgitation is observed over time, with low reoperation risk, supporting its continued use.
Study context
- Population
- Patients undergoing the Ozaki procedure (aortic valve cusp replacement with autologous pericardium) for aortic valve disease, Toho University Ohashi Medical Center, April 2007 to May 2021
- Participants
- 1,196 patients
- Outcome
- Longitudinal hemodynamics, LV reverse remodeling, reoperation and survival
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Mean aortic valve gradient at 6 months, 5 years and 10 years
- 7.4, 8.0, and 8.2 mm Hg
- ≥2+ regurgitation at 6 months, 5 years and 10 years
- 0.30%, 2.9%, and 6.6%
- LV mass index, preoperatively
- 141 ± 52 g/m²
- LV mass index at 10 years
- 90 ± 51 g/m²
- Survival at 10 years
- 78%
- Freedom from reoperation at 10 years
- 92%
Observational data: associations, not effects.
Further findings
Cardiopulmonary bypass and aortic clamp times (isolated Ozaki procedures)
- Mean cardiopulmonary bypass time
- 151 ± 37 minutes
- Mean aortic clamp time
- 105 ± 29 minutes
Safety
Early outcomes
- 30-day mortality
- 1.7%
- New stroke
- 2.6%
- New dialysis
- 4.0%
- Permanent pacemaker
- 1.5%
Original publication
Mid-Term Experience With 1,196 Ozaki Procedures. JACC Adv. Published 21 October 2025. doi:10.
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