Impact of standard modifiable cardiovascular risk factors on 2-year all-cause mortality: Insights from an international cohort of 23,489 patients with acute coronary syndrome
Authors' conclusion
In this large-scale international ACS cohort the absence of SMuRFs was not associated with a lower adjusted 2-year postdischarge mortality risk.
Study context
- Population
- Acute coronary syndrome (ACS) patients in Europe, Latin America and Asia (EPICOR and EPICOR Asia registries, 2010–2014)
- Participants
- 23,489 patients
- Exposure
- SMuRFs vs no SMuRFs
- Without SMuRFsn = 4,582reference
- Outcome
- All-cause mortality
- Follow-up
- 2 years postdischarge
Methodological detailsinternational, multicentre (28 countries), adjusted Cox models stratified by geographical region
- International
- Multicentre (28 countries)
- Adjusted Cox models stratified by geographical region
Main finding
As reported in the abstract
2-year postdischarge mortality · 2 years
SMuRFs vs Without SMuRFsHazard ratio (95% CI)P value
Adjusted; regardless of type of ACS
1.17(0.98–1.41)
P = 0.087Crude
1.86(1.56–2.22)
P < 0.001Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| 2-year mortality, women with SMuRFs and prior CVDvs women without SMuRFs and without CVD | 1.67 (1.34–2.06) | |
| 0.512Hazard ratio (log scale) |
Original publication
Impact of standard modifiable cardiovascular risk factors on 2-year all-cause mortality: Insights from an international cohort of 23,489 patients with acute coronary syndrome. Am Heart J. Published 4 June 2023. doi:10.
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