Multicenter Evaluation of the Feasibility of Clinical Implementation of SPECT Myocardial Blood Flow Measurement: Intersite Variability and Imaging Time
Authors' conclusion
The average bias-MBF and bias-MFR values were small with standard deviations substantially less than the test-retest variability. This demonstrates that MBF can be measured consistently across multiple sites and further supports that this technique can be reliably implemented.
Study context
- Population
- Patients with intermediate to high pretest probability of CAD undergoing rest and pharmacological stress Tc-99m-tetrofosmin CZT SPECT myocardial blood flow (MBF) studies at 5 sites (Canada, Italy, Japan, Germany, Singapore)25 to 35 studies per site
- Comparison
- Local-site vs core-laboratory SPECT MBF processing
- Outcome
- Intersite processing repeatability of SPECT MBF and additional camera time required
Methodological details5 sites, core laboratory comparison
- 5 sites
- Core laboratory comparison
Main finding
As reported in the abstract
- Correlation, MBF at rest
- 0.93 (range, 0.87-0.97)
- Correlation, MBF at stress
- 0.90 (range, 0.84-0.96)
- Correlation, myocardial flow reserve
- 0.84 (range, 0.70-0.92)
- Bias-MBF at rest, median (IQR)
- 5.4% (−3.8% to 14.8%)
- Bias-MBF at stress, median (IQR)
- 5.4% (−6.2% to 19.4%)
- Bias-MBF range between sites at rest
- −1.6% to 11.0%
- Bias-MBF range between sites at stress
- −1.9% to 16.3%
- IQR in bias-MBF between sites at rest
- between 9.3% (4.8%-14.0%) and 22.3% (−10.3% to 12.0%)
- IQR in bias-MBF between sites at stress
- between 17.0% (−11.3% to 5.6%) and 33.3% (−10.4% to 22.9%)
- Overall difference in myocardial flow reserve
- 1.52% (−10.6% to 11.3%)
- Additional acquisition time, average, range between sites
- 44 to 79 minutes
Further findings
- No significant differences between with and without motion correction
Original publication
Multicenter Evaluation of the Feasibility of Clinical Implementation of SPECT Myocardial Blood Flow Measurement: Intersite Variability and Imaging Time. Circ Cardiovasc Imaging. Published 6 October 2023. doi:10.
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