Impact of treatment delay on mortality in ST-segment elevation myocardial infarction (STEMI) patients presenting with and without haemodynamic instability: results from the German prospective, multicentre Feedback Intervention and Treatment Times in ST-Elevation Myocardial Infarction (FITT-STEMI) trial
Authors' conclusion
In patients with CS, the time elapsing from the first medical contact to primary PCI is a strong predictor of an adverse outcome.
Study context
- Population
- STEMI patients transported by emergency medical service and treated with primary percutaneous coronary intervention (PCI)
- Participants
- 12,675 patients
- Comparison
- Effect of contact-to-balloon time on mortality by haemodynamic status
- Primary endpoint
- Mortality in relation to first medical contact-to-balloon time
Methodological detailsmulticentre
- Multicentre
Primary result
As reported in the abstract
Additional deaths per 100 PCI-treated patients per 10-min treatment delay (contact-to-balloon 60–180 min)
- Delay-related mortality increase significantly higher in cardiogenic shock (CS) without out-of-hospital cardiac arrest (OHCA) than in the other three groups
- P < 0.0001
Original publication
Impact of treatment delay on mortality in ST-segment elevation myocardial infarction (STEMI) patients presenting with and without haemodynamic instability: results from the German prospective, multicentre FITT-STEMI trial. Eur Heart J. Published 14 February 2018. doi:10.
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