Heart failure & cardiomyopathies
Impaired Exercise Capacity in High-Risk Diabetic Cardiomyopathy: The ARISE-HF Cardiopulmonary Exercise Testing Subanalysis
Authors' conclusion
Baseline cardiopulmonary exercise testing data from the ARISE-HF trial highlight predominant associations of extracardiac clinical and demographic variables with significant impairment in exercise capacity despite strict fulfillment of diagnostic criteria for stage B HF.
Study context
- Population
- Participants with diabetic cardiomyopathy and stage B heart failure at high risk for overt heart failure (HF)
- Participants
- 689 study participants
- Outcome
- Peak oxygen uptake and ventilatory efficiency (slope of the ratio of minute ventilation/carbon dioxide production)
- Follow-up
- Baseline
Methodological detailscardiopulmonary exercise testing subanalysis, cluster analysis
- Cardiopulmonary exercise testing subanalysis
- Cluster analysis
Main finding
As reported in the abstract
baseline
Peak oxygen uptake, median (interquartile range), mL/kg per minute
15.7
interquartile range, 13.0–18.0
Ventilatory efficiency, median (interquartile range)
31.2
interquartile range, 27.2–34.1
Observational data: associations, not effects.
Further findings
Correlates of lower peak oxygen uptake · baseline
- Lower peak oxygen uptake associated with older age, female sex, higher body mass index, higher N-terminal pro-B-type natriuretic peptide, and an increasing burden of noncardiac comorbid conditions
- Not associated with cardiac troponin T or echocardiogram-derived strain, left atrial volume index, E/e′, or right ventricular systolic pressure
- Elevated left ventricular mass index was the only echocardiographic abnormality associated with lower peak oxygen uptake
- Independently associated with lower baseline peak oxygen uptake (multivariable): female sex, higher body mass index, and no history of dyslipidemia
Cluster analysis
- 3 clusters with profiles of different cardiovascular/exercise parameters and health status profiles
Original publication
Impaired Exercise Capacity in High-Risk Diabetic Cardiomyopathy: The ARISE-HF Cardiopulmonary Exercise Testing Subanalysis. Circ Heart Fail. Published 30 January 2025. doi:10.
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