Heart failure & cardiomyopathies
Impaired Left Atrial Reserve Function in Heart Failure With Preserved Ejection Fraction
Main finding · HF eventsResult — go to the resultHazard ratio 2.66 95% CI 1.32–5.38Authors' conclusion
Impaired LA reservoir function during exercise in HF with preserved ejection fraction is associated with biventricular reserve limitations, exercise intolerance, and increased risks of HF events.
Study context
- Population
- Patients with HFpEF and controls without heart failure (HF) undergoing exercise stress echocardiography with expired gas analysis
- Participants
- 231 vs 219
- Exposure
- HFpEF vs controls without HF; lower vs higher exercise left atrial (LA) reservoir strain
- HF with preserved ejection fractionn = 231
- Controlsn = 219reference
- Outcome
- Association of abnormal LA dynamics during exercise with cardiovascular reserve, exercise capacity and clinical outcomes
Main finding
HF events
Hazard ratio
2.66
95% CI 1.32–5.38
P = 0.006
Lower exercise LA reservoir strain
HR 2.66 (95% CI 1.32–5.38); P = 0.006
As reported in the abstract
- LA dilation more closely related to exercise LA reservoir strain than to resting LA strain (Meng test)
- P = 0.002
Observational data: associations, not effects.
Further findings
LA reservoir and booster pump strain after GDMT initiation or AF ablation (patients with follow-up echocardiography)
- Improved LA reservoir strain at rest
- P < 0.001
- Improved LA reservoir strain during exercise
- P = 0.022
- Improved booster pump strain at rest
- P = 0.011
- Improved booster pump strain during exercise
- 0.028
Original publication
Impaired Left Atrial Reserve Function in Heart Failure With Preserved Ejection Fraction. Circ Cardiovasc Imaging. Published 20 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →