Heart failure & cardiomyopathies
Implementation of Guidelines for Intravenous Iron Therapy in Heart Failure Patients
Authors' conclusion
In patients with HFrEF and HFmrEF, 54% were screened for iron deficiency. Screened patients had more advanced HF disease, possibly due to increased medical attention and higher compliance to guideline recommended treatment.
Study context
- Population
- Patients with left ventricular ejection fraction (LVEF) < 50% and New York Heart Association (NYHA) class II–IV visiting Karolinska University Hospital in 2021
- Participants
- 261 patients
- Exposure
- Screened vs unscreened for iron deficiency
- Screenedn = 141
- Outcome
- Implementation of 2021 ESC Guidelines on screening and treatment of iron deficiency in heart failure (HF)
Methodological detailssingle-centre, SwedeHF registry
- Single-centre
- SwedeHF registry
Main finding
As reported in the abstract
Screening for iron deficiency
Screened
54%
141
Observational data: associations, not effects.
Further findings
Characteristics, screened vs unscreened
LVEF
NT-proBNP Screened 2880 ng/L · Unscreened 1960 ng/L
Diabetes
SGLT2i
Loop diuretics
- Characteristics, screened vs unscreened: LVEF P = 0.033
- Characteristics, screened vs unscreened: NT-proBNP P = 0.040
- Characteristics, screened vs unscreened: diabetes P = 0.030
- Characteristics, screened vs unscreened: SGLT2i and loop diuretics both P < 0.001
NYHA class, IV iron treated vs untreated with indication
- Higher NYHA class in patients treated with IV iron
- P = 0.038
Original publication
Implementation of Guidelines for Intravenous Iron Therapy in Heart Failure Patients. ESC Heart Fail. Published 21 June 2025. doi:10.
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