Valvular & structural heart disease
Implications of an off-hours setting in patients undergoing transcatheter edge-to-edge repair for mitral regurgitation
Authors' conclusion
A noninfrequent procedure, off-hours mitral TEER is performed in high-risk cases but, in the hands of experienced interventionalists, should prove safe, feasible, and efficacious.
Study context
- Population
- Patients undergoing isolated, first-time mitral transcatheter edge-to-edge repair (TEER) for mitral regurgitation (MR)procedures studied · off-hours 117 · 1-to-1 matched sub-cohort 234
- Participants
- 1,177 procedures
- Exposure
- Mitral TEER initiated off-hours vs during usual working hours
- Off-hoursn = 117
- Outcome
- Urgent interventions
Methodological detailsretrospectively analyzed, propensity-score matching
- Retrospectively analyzed
- Propensity-score matching
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
Deaths · first postprocedural year · occurred earlier following off-hours procedures
Composite of deaths or HF hospitalizations · first postprocedural year
- Deaths: P = .022
- Composite of deaths or heart failure (HF) hospitalizations: P = .040
Technical success
- High technical success rate achieved unanimously
- >97%
MR severity and functional class
- Similarly improved from baseline in the 2 study groups
Independent association of endpoint risks with procedural timing
- None of the explored endpoints' risks were independently associated with procedural timing
Matched sub-cohort findings and outcomes
- No inter-group differences in pre-, intra-, and postprocedural findings and outcomes
- 234-patient, 1-to-1 matched sub-cohort
Original publication
Implications of an off-hours setting in patients undergoing transcatheter edge-to-edge repair for mitral regurgitation. Am Heart J. Published 2 January 2025. doi:10.
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