Heart failure & cardiomyopathies
Improved Survival in Octogenarians With Heart Failure: 15-Year Cohort Study From a National Referral Center
Authors' conclusion
Over a 15-year period, mortality risks among octogenarians and older with HF decreased, especially in HFpEF and nonfrail patients.
Study context
- Population
- Heart failure (HF) patients treated at a single tertiary centre, 2009–2024
- Participants
- 32,892 patients
- Exposure
- Octogenarians or older vs nonoctogenarians, early vs later period
- Octogenarians or oldern = 11,013
- Nonoctogenariansn = 21,879reference
- Outcome
- All-cause mortality
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Mortality · 5 years
Octogenarians or older vs NonoctogenariansAdjusted hazard ratio (95% CI)P value
Early period (before June 2016)
2.1(2.03–2.19)
P < 0.001Later period
1.6(1.57–1.75)
P < 0.001 for interactionObservational data: associations, not effects.
Further findings
Mortality HR (octogenarians vs nonoctogenarians), early vs late period, by HF type
- HFpEF: HR declined 2.02 to 1.62
- P for interaction < 0.001
- HFrEF: HR 2.25 to 2.00, no significant decline
- P for interaction = 0.400
Mortality HR change by frailty
- Decreases in mortality HR between early and late period significant in nonfrail patients
Guideline-directed medical therapy use
- Increased over time
Original publication
Improved Survival in Octogenarians With Heart Failure: 15-Year Cohort Study From a National Referral Center. JACC Adv. Published 29 October 2025. doi:10.
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