Heart failure & cardiomyopathies
Tricuspid Regurgitation Across the Spectrum of Heart Failure With Preserved Ejection Fraction
Authors' conclusion
STR in HFpEF is associated with PVD and less strongly with higher resting filling pressure.
Study context
- Population
- Patients evaluated with hemodynamics (rest and leg-elevation or exercise), including heart failure with preserved ejection fraction (HFpEF) phenotypes and noncardiac dyspnea669 (61.3%) with HFpEF
- Participants
- 1,091 patients
- Exposure
- HFpEF phenotypes by pulmonary vascular disease (PVD) and rest vs provoked filling pressure elevation; atrial vs ventricular secondary tricuspid regurgitation (STR)
- Outcome
- Prevalence, distribution and prognostic significance of STR mechanisms across HFpEF
Main finding
As reported in the abstract
Moderate or severe STR
- Moderate or severe STR overall
- 17.4%
- Exercise-only HFpEF vs noncardiac dyspnea: moderate or severe STR 11.7% vs 6.5%
- P = 0.047
- STR fulfilling criteria for V-STR
- 69%
Observational data: associations, not effects.
Further findings
| Outcome | Multivariable HR (95% CI) | |
|---|---|---|
| Death or HF hospitalization (composite)Also associated with death and HF hospitalization each alone | 1.70 (1.10–2.65) | |
| 0.20.5125Multivariable hazard ratio (log scale) |
Heart failure (HF) hospitalization
| Multivariable Fine-Gray HR (95% CI) | ||
|---|---|---|
| A-STR | 2.21 (1.12–4.37) | |
| 0.20.5125Multivariable Fine-Gray HR (log scale) |
AF and atrial remodeling, V-STR vs A-STR
- V-STR had similar AF prevalence and greater atrial remodeling vs A-STR
Original publication
Tricuspid Regurgitation Across the Spectrum of Heart Failure With Preserved Ejection Fraction. J Am Coll Cardiol. Published 29 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →