Arrhythmias & electrophysiology
Improving guideline-based anticoagulation in atrial fibrillation: A systematic literature review of prospective trials
Authors' conclusion
Interventions aimed at improving anticoagulation prescribing patterns in AF can be effective, although there is heterogeneity in outcomes across intervention type. The most effective interventions appeared to target patient education, provider education, and electronic risk assessment or decision support.
Study context
- Population
- Patients with atrial fibrillation (AF) with an indication for anticoagulation20 trials
- Comparison
- Population-based interventions to decrease the AF anticoagulation gap
- Outcome
- Efficacy in decreasing the AF anticoagulation gap (anticoagulation prescribing)
Methodological detailsindividually randomised and cluster randomised trials, prospectively registered, Search of PubMed, Google Scholar, Web of Science and Medline; 1474 studies reviewed
- Individually randomised and cluster randomised trials
- Prospectively registered
- Search of PubMed, Google Scholar, Web of Science and Medline; 1474 studies reviewed
Pooled result
As reported in the abstract
Trials effective in decreasing the AF anticoagulation gap
| Outcome | Patient education | Provider education | Electronic risk assessment or decision support |
|---|---|---|---|
| Absolute increase in appropriate anticoagulation prescribing | 8.3% | 4.9% | 2.0% |
- Trials effective in decreasing the AF anticoagulation gap
- 45%
Further pooled results
Trials improving anticoagulation prescribing, by setting
- Ambulatory trials
- 6 of 15
- Inpatient trials
- 2 of 4
- Inpatient and outpatient trial
- 1
Original publication
Improving guideline-based anticoagulation in atrial fibrillation: A systematic literature review of prospective trials. Heart Rhythm. Published 17 September 2022. doi:10.
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