In-hospital prognosis of acute ST-elevation myocardial infarction in patients with recent recreational drug use
Authors' conclusion
In patients with STEMI, recreational drug use is prevalent, especially in patients under 50 years of age, and is independently associated with an increase of MACEs with more ventricular arrhythmia.
Study context
- Population
- Consecutive patients admitted for ST-elevated myocardial infarction (STEMI) in 39 intensive cardiac care units (ICCUs) across France, 7–22 April 2021
- Participants
- 325 patients
- Exposure
- Recreational drug users vs non-users
- Recreational drug usersn = 41
- Outcome
- In-hospital MACE:
- Death
- Resuscitated cardiac arrest
- Cardiogenic shock
- Follow-up
- During hospitalization
Methodological detailsmulticentre, 39 ICCUs across France, consecutive patients, systematic urine multidrug test
- Multicentre
- 39 ICCUs across France
- Consecutive patients
- Systematic urine multidrug test
Main finding
As reported in the abstract
- Recreational drug use associated with more MACE after adjustment for comorbidities, OR
- 13.1 (3.4-54.6) (95% CI)
Observational data: associations, not effects.
Further findings
Ventricular arrhythmia · During hospitalization
- Ventricular arrhythmia: P = 0.01
Prevalence of positive urine multidrug test
- Positive multidrug test, all patients
- 41 (12.6%)
- Cannabis
- 11.1%
- Opioids
- 4.6%
- Cocaine
- 1.2%
- Methylenedioxymethamphetamine
- 0.6%
- Positive test, patients under 50 years
- 34.0%
In-hospital MACE and components, all patients · During hospitalization
- MACE
- 17 (5.2%)
- Deaths
- 6 (1.8%)
- Cardiogenic shocks
- 10 (3.1%)
- Resuscitated cardiac arrests
- 7 (2.2%)
Original publication
In-hospital prognosis of acute ST-elevation myocardial infarction in patients with recent recreational drug use. Eur Heart J Acute Cardiovasc Care. Published 21 February 2024. doi:10.
Summarised from the published abstract; every number is checked against it