Heart failure & cardiomyopathies
In-hospital prognostic value of TAPSE/sPAP in patients hospitalized for acute heart failure
Authors' conclusion
TAPSE/sPAP < 0.40 mm/mmHg assessed by an early echocardiography during an AHF episode is independently associated with in-hospital MACEs
Study context
- Population
- Patients hospitalized for acute heart failure (mean age 68 ± 14 years, 70% male, mean LVEF 44 ± 16%)external validation cohort 133
- Participants
- 333 patients
- Exposure
- TAPSE/sPAP < 0.40 vs ≥ 0.40 mm/mmHg
- Outcome
- In-hospital MACE:
- All-cause death
- Resuscitated cardiac arrest
- Cardiogenic shock
- Follow-up
- In-hospital
Methodological detailsmulticentre, 39 French cardiology departments, consecutive patients
- Multicentre
- 39 French cardiology departments
- Consecutive patients
Main finding
As reported in the abstract
In-hospital MACE
TAPSE/sPAP < 0.40 vs TAPSE/sPAP ≥ 0.40Odds ratio (95% CI)P value
Adjusted for comorbidities
3.75(1.87–7.93)
P < 0.001Adjusted for clinical severity
2.80(1.36–5.95)
P = 0.0061:1 propensity-matched population
2.98(1.53–6.12)
P = 0.002- In-hospital MACE, overall
- 50 (15%)
- Best ROC threshold for in-hospital MACE
- 0.40 mm/mmHg
Observational data: associations, not effects.
Further findings
Incremental prognostic value above traditional factors
- C-statistic improvement
- 0.05
- χ2 improvement
- 14.4
- Likelihood-ratio test
- P < 0.001
External validation cohort
- Results consistent in external validation cohort of 133 patients
Original publication
In-hospital prognostic value of TAPSE/sPAP in patients hospitalized for acute heart failure. Eur Heart J Cardiovasc Imaging. Published 1 March 2024. doi:10.
Summarised from the published abstract; every number is checked against it