Arrhythmias & electrophysiology
Incidence and predictors of tricuspid regurgitation after left bundle branch area pacing: A Korean multicenter registry study
Authors' conclusion
Incident TR occurred in 6.7% of patients following successful LBBAP. LVSP, prevalent AF, elevated TR Vmax, and prolonged QRS duration were independent predictors of incident TR.
Study context
- Population
- Patients who underwent successful left bundle branch area pacing (LBBAP) between 2021 and 2024 and had no or mild tricuspid regurgitation (TR) at baseline
- Participants
- 523 patients
- Exposure
- Patients with incident TR vs patients without incident TR
- Outcome
- Incident TR, defined as new-onset moderate-or-greater TR on follow-up echocardiography
- Follow-up
- 1-year follow-up
Methodological detailsretrospective, 31 centers
- Retrospective
- 31 centers
Main finding
As reported in the abstract
Patients who developed incident TR
35
6.7%
Observational data: associations, not effects.
Further findings
Independent predictors of incident TR (multivariable analysis)
| Comparison | OR (95% CI) | |
|---|---|---|
| AFMultivariable logistic regression | 12.55 (3.18–49.55) | |
| LVSPMultivariable logistic regression | 9.08 (2.35–35.12) | |
| Baseline TR Vmax of ≥2.8 m/secondMultivariable logistic regression | 4.19 (1.20–14.60) | |
| Baseline QRS duration of ≥120 msMultivariable logistic regression | 3.80 (1.01–14.32) | |
| 0.050.21520Odds ratio (log scale) |
Characteristics of patients with vs without incident TR
- Patients with incident TR had a significantly higher prevalence of atrial fibrillation (AF), higher baseline TR Vmax, longer baseline QRS duration, and a higher frequency of left ventricular septal pacing (LVSP)
Original publication
Incidence and predictors of tricuspid regurgitation after left bundle branch area pacing: A Korean multicenter registry study. Heart Rhythm. Published 21 July 2026. doi:10.
Summarised from the published abstract; every number is checked against it