Heart failure & cardiomyopathies
Incidence, Mortality, and Predictors of Acute Kidney Injury in Patients with Heart Failure: A Systematic Review
Authors' conclusion
In this meta-analysis, AKI occurred in approximately 33% of HF patients during hospitalization and the risk of dying in the hospital was tripled.
Study context
- Population
- Patients with heart failure (HF)
- Participants
- 3,533,583 patients37 studies
- Outcome
- Incidence of AKI
Methodological detailsEmbase, Medline, PubMed, Cochrane and Web of Science searched from inception to October 2022
- Embase, Medline, PubMed, Cochrane and Web of Science searched from inception to October 2022
Pooled result
As reported in the abstract
Patients with acute kidney injury (AKI)
774 887
Pooled incidence of AKI
33%
95% CI 32–35%
Incidence in acute HF
36%
95% CI 31–40%
Incidence in chronic HF
30%
95% CI 24–35%
Further pooled results
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| In-hospital mortality, AKIvs non-AKI11 studies | 3.65 (3.04–4.39) | P < 0.001 | |
| 0.20.5125Relative risk (log scale) |
Mortality after onset of AKI · 1-year follow-up
| RR (95% CI) | P value | ||
|---|---|---|---|
| AKI5 studies | 1.85 (1.54–2.22) | P < 0.001 | |
| 0.512Relative risk (log scale) |
Admission predictors of AKI (15 variables, 13 studies)
- DM, hypertension, history of CKD, chronic HF systolic, age, NT-proBNP, creatinine > 1.0 mg/dL, eGFR < 60 mL/min/1.73 m², BUN > 24 mg/dL, IV dobutamine and serum albumin predicted AKI
- P < 0.05
Original publication
Incidence, Mortality, and Predictors of Acute Kidney Injury in Patients with Heart Failure: A Systematic Review. ESC Heart Fail. Published 13 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →