Heart failure & cardiomyopathies
Phenotyping left ventricular systolic dysfunction in asymptomatic individuals for improved risk stratification
Authors' conclusion
Clustering of clinical variables identified three distinct risk profiles and clinical trajectories of LVSD amongst initially asymptomatic subjects.
Study context
- Population
- UK Biobank participants without pre-existing heart failure (HF) and with left ventricular ejection fraction (LVEF) < 50% on cardiovascular magnetic resonance (CMR)
- Participants
- 1,563 participants
- Exposure
- Cluster 2 and Cluster 3 vs Cluster 1
- Outcome
- Clinical phenotypes of LVSD and their association with clinical outcomes (HF, other CV events, death, major adverse cardiovascular events (MACE))
Methodological detailsUK Biobank, unsupervised clustering of 60 clinical variables
- UK Biobank
- Unsupervised clustering of 60 clinical variables
Main finding
As reported in the abstract
MACE
Cluster 2
1.42
95% CI 1.03–1.96P < 0.05
Cluster 3
1.72
95% CI 1.36–2.35P < 0.001
Observational data: associations, not effects.
Further findings
CV imaging characteristics
- Cluster 3 had the greatest LV remodelling, myocardial dysfunction and decrease in arterial compliance
Original publication
Phenotyping left ventricular systolic dysfunction in asymptomatic individuals for improved risk stratification. Eur Heart J Cardiovasc Imaging. Published 12 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →