Coronary disease & ACSCohort study
Incidence of Dementia in Older Adults Hospitalized With Acute Coronary Syndrome
- longitudinal cohort study
- propensity-matched analyses
- Cox models accounting for the competing risk of death
Authors' conclusion
We found that among older adults with ACS, coronary revascularization was not statistically significantly associated with increased dementia risk compared with no revascularization or stable CAD. These findings reflect the hypothesis that the majority of dementia risk is potentially driven more by cumulative vascular and systemic factors than by procedure-specific neurotoxicity.
Study context
- Population
- Adults aged ≥65 years hospitalized for ACS between 2010 and 2020ACS patients, second comparator cohort of stable coronary artery disease (CAD) without revascularization n = 154,299 · percutaneous coronary intervention 8,043 · coronary artery bypass grafting 797 · no revascularization 16,336 · stable CAD without revascularization 154,299
- Participants
- 25,176 adults
- Exposure
- Revascularization vs ACS without revascularization or stable CAD
- percutaneous coronary interventionn = 8,043
- coronary artery bypass graftingn = 797
- no revascularizationn = 16,336
- stable CADn = 154,299
- Outcome
- Incident dementia identified using validated International Classification of Diseases codes after a 1-year washout
- Follow-up
- Median 4.8 years
Main finding
As reported in the abstract
Sub-hazard ratio
1.05
95% CI 0.95–1.17
Revascularization vs no revascularization
sub-hazard ratio 1.05 (95% CI 0.95–1.17)
- ACS patients who developed dementia
- 9.0%
Observational data: associations, not effects.
Further findings
Baseline characteristics, revascularized vs not
- Age, years
- 74.8 ± 6.9 vs 77.1 ± 8.2
- Male
- 66.2% vs 54.0%
- Elixhauser multimorbidity score
- 4.6 ± 2.8 vs 5.4 ± 3.0
- all P < 0.001
Original publication
Incidence of Dementia in Older Adults Hospitalized With Acute Coronary Syndrome. JACC Adv. Published 28 August 2026. doi:10.1016/j.jacadv.2026.103192
Summarised from the published abstract; every number is checked against it