Valvular & structural heart disease
Incidence, predictors and outcomes of tricuspid regurgitation progression after left-sided valvular intervention
Authors' conclusion
TR progression is common after left-sided VHD correction and is associated with adverse outcomes. Indexing TAD to body surface area mitigates sex differences in risk assessment.
Study context
- Population
- Patients without severe tricuspid regurgitation (TR) undergoing surgical or transcatheter treatment for aortic or mitral disease, 2014–2018
- Participants
- 1,644 patients
- Exposure
- TR progression vs no TR progression
- Outcome
- Incidence of TR progression (increase to moderate or severe TR)
- Follow-up
- 5 years
Main finding
As reported in the abstract
TR progression incidence
TR progression incidence
12.0%
95% CI 10.5% to 13.7%
Observational data: associations, not effects.
Further findings
TR progression by tricuspid annular diameter (TAD); linear relationship
| HR (95% CI) | P value | ||
|---|---|---|---|
| TAD | 1.08 (1.04–1.11) | P < 0.001 | |
| 0.512Hazard ratio (log scale) |
| Outcome | Adjusted HR (95% CI) | P value | |
|---|---|---|---|
| All-cause mortality with TR progression | 2.77 (2.16–3.56) | P < 0.001 | |
| Death or HF hospitalisation with TR progression | 2.91 (2.21–3.82) | P < 0.001 | |
| 0.20.5125Adjusted hazard ratio (log scale) |
- TR progression by tricuspid annular diameter (TAD); linear relationship: sex differences mitigated by indexing TAD to body surface area
Baseline predictors of TR progression
- Older age, female sex, AF, prior pacemaker implantation and larger TAD associated with TR progression
Original publication
Incidence, predictors and outcomes of tricuspid regurgitation progression after left-sided valvular intervention. Heart. Published 30 April 2025. doi:10.
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