Incidence rate of coronary atherosclerosis among cancer types during survivorship: A systematic review and meta-analysis
Authors' conclusion
Cancer survivors are at an increased risk of developing coronary atherosclerosis compared to the noncancer population, especially over a longer follow-up period.
Study context
- Population
- Adult cancer survivors
- Participants
- 8,099,752 survivors · 18 studies
- Comparison
- Cancer survivors vs noncancer population
- Outcome
- Risk of coronary atherosclerosis vs general population, as risk difference
Methodological detailsRisk of bias of included studies low; no evidence of publication bias
- Risk of bias of included studies low; no evidence of publication bias
Pooled result
As reported in the abstract
Coronary atherosclerosis by cancer type
- Survivors of hematological, renal and testicular cancer more likely to be diagnosed with coronary atherosclerosis vs noncancer population
Further pooled results
| Outcome | Survivors | Controls | RD (95% CI) | P value | |
|---|---|---|---|---|---|
| Coronary atherosclerosis, longer follow-up · >10 years | 17% | 8% | 0.12 (0.03–0.22) | P < 0.001 | |
| −0.100.10.20.3Difference (linear scale) |
CV risk factors contributing to risk difference
- Hypercholesterolemia β = 0.012
- P < 0.001
- Hypertension β = 0.008
- P = 0.017
- Obesity β = 0.008
- P = 0.021
Original publication
Incidence rate of coronary atherosclerosis among cancer types during survivorship: A systematic review and meta-analysis. Am Heart J. Published 23 April 2025. doi:10.
Summarised from the published abstract; every number is checked against it