Incident cancer in heart failure, myocardial infarction or both: a report from a global federated research network
Authors' conclusion
In this large, real-world cohort, both HF and AMI were associated with an increased incidence of cancer, particularly haematologic malignancies. HF was associated with a greater excess risk than AMI.
Study context
- Population
- Adults with a first hospitalization for acute heart failure (HF) or acute myocardial infarction (AMI), October 2015–October 2024, without prior or concurrent cancermatched cohort
- Exposure
- HF or AMI vs matched controls without HF or AMI
- HFn = 120,783
- AMIn = 7,896
- Outcome
- Any new cancer diagnosis
- Follow-up
- From 6 months after the index hospitalization
Methodological detailspropensity-score matched, federated research network (TriNetX)
- Propensity-score matched
- Federated research network (TriNetX)
Main finding
As reported in the abstract
Incident cancer · median follow-up 13 months (HF), 16 months (AMI) after 6-month landmark
Each group vs controlsHazard ratio (95% CI)P value
HF
2.80(2.69–2.91)
P < 0.001AMI
2.02(1.71–2.39)
P < 0.001Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Cancer incidence by HF phenotypeHF with preserved ejection fractionvs HF with reduced or mildly reduced ejection fraction | 1.10 (1.04–1.17) | P = 0.002 | |
| 0.512Hazard ratio (log scale) |
Cancer incidence, haematologic vs solid malignancies
- HF: haematologic vs solid HR
- 6.78 vs 2.53
- AMI: haematologic vs solid HR
- 4.45 vs 1.77
- Excess risk more pronounced for haematologic than solid malignancies
Cancer incidence, ST vs non-ST segment elevation AMI
- No difference between ST and non-ST segment elevation AMI
Original publication
Incident cancer in heart failure, myocardial infarction or both: a report from a global federated research network. Eur J Heart Fail. Published 10 May 2026. doi:10.
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