The influence of social deprivation in infective endocarditis: a retrospective observational study of the London endocarditis research network
Authors' conclusion
These findings suggest that greater co-morbidity, higher inflammatory markers and reduced surgical intervention contribute to higher mortality in socially deprived patients within a universal healthcare system.
Study context
- Population
- Infective endocarditis (IE) patient visits at three London centers between December 2013 and March 2023, stratified by social deprivation measured with the Index of Multiple DeprivationKing’s College Hospital NHS Foundation Trust, Guy’s & St. Thomas’ NHS Foundation Trust and Barts Health NHS Trust (three centers) 1,740
- Participants
- 1,740 IE patient visits
- Exposure
- High vs Medium vs Low SD groups
- Highn = 638
- Mediumn = 576
- Lown = 526
- Outcome
- All-cause mortality
- Follow-up
- 30 days and 1 year
Methodological detailsthree centers in London, universal healthcare system
- Three centers in London
- Universal healthcare system
Main finding
As reported in the abstract
- Significantly higher in the High SD group at 30 days
- P = 0.030
- Significantly higher in the High SD group at 1 year
- P = 0.004
Observational data: associations, not effects.
Further findings
Patient characteristics
- High SD group more likely to be female
- P < 0.001
- High SD group more likely from Asian self-reported racial group
- P < 0.001
- High SD group more likely from Black self-reported racial group
- P < 0.001
- High SD group had more co-morbidity, including more people who inject drugs
- P < 0.001
Presentation
- High SD group: higher white cell count
- P = 0.025
- High SD group: higher C-reactive protein
- P = 0.001
- High SD group: higher rates of right-sided IE
- P = 0.028
Causative organism established
- Causative organism established
- 77.1%
- No differences between groups
Surgical management
- Significantly lower rates of surgery in the High SD group
- P < 0.001
- Significantly more patients managed conservatively despite having a surgical indication
- P = 0.003
Original publication
The influence of social deprivation in infective endocarditis: a retrospective observational study of the London endocarditis research network. Eur Heart J Qual Care Clin Outcomes. Published 22 September 2025. doi:10.
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