Incident Myocardial Infarction, Heart Failure, and Oncologic Outcomes in Breast Cancer Survivors
Authors' conclusion
Incident MI and/or HF after breast cancer treatment are associated with higher hazards of adverse oncologic outcomes
Study context
- Population
- Women with first breast cancer (2007–2015), Ontario, Canada, alive 2 years after diagnosis, aged ≥40, without recurrent/distant disease or preceding cardiovascular disease (CVD)median age 60 years
- Participants
- 30,694 women
- Exposure
- Incident myocardial infarction (MI)/heart failure (HF) vs no incident MI/HF
- Incident MI/HFn = 1,346
- Outcome
- Cancer mortality, new non-breast malignancy, new chemotherapy initiation
Methodological detailslandmark analysis, time-varying exposure, multivariable cause-specific hazards regression
- Landmark analysis
- Time-varying exposure
- Multivariable cause-specific hazards regression
Main finding
As reported in the abstract
Incident MI/HF vs No incident MI/HFHazard ratio (95% CI)
Cancer death
3.94(3.38–4.59)
Non-breast malignancy
1.39(1.06–1.82)
New chemotherapy
1.25(1.02–1.53)
Observational data: associations, not effects.
Further findings
Cumulative incidence, whole cohort · 5 years
- Cancer death
- 5.9% (95% CI: 5.6%-6.1%)
- Non-breast malignancy
- 4.3% (95% CI: 4.1%-4.6%)
- New chemotherapy
- 25.7% (95% CI: 25.2%-26.2%)
Original publication
Incident Myocardial Infarction, Heart Failure, and Oncologic Outcomes in Breast Cancer Survivors. JACC CardioOncol. Published 5 November 2024. doi:10.
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