Incorporating a polygenic risk score-triaged coronary calcium score into cardiovascular disease examinations to identify subclinical coronary artery disease (ESCALATE): Protocol for a prospective, nonrandomized implementation trial
Study context
- Population
- Adults aged 45 to 65 years at low or moderate 5-year absolute CVD risk in primary care CVD risk assessment; those with coronary artery disease (CAD) polygenic risk scores (PRS) ≥80% triaged for coronary calcium scanplanned enrolment
- Participants
- 1,000 adults
- Primary endpoint
- Identification of subclinical CAD (CACS >0 AU)
Methodological detailsmulticentre, 12-month, Secondary outcomes: baseline coronary artery calcium score (CACS) ≥100 Agatston units (AU) or ≥75th age-/sex-matched percentile, use and intensity of lipid- and BP-lowering therapy, cholesterol and BP levels, health-related quality of life (HRQOL)
- Multicentre
- 12-month
- Secondary outcomes: baseline CACS ≥100 AU or ≥75th age-/sex-matched percentile, use and intensity of lipid- and BP-lowering therapy, cholesterol and BP levels, HRQOL
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Incorporating a polygenic risk score-triaged coronary calcium score into cardiovascular disease examinations to identify subclinical coronary artery disease (ESCALATE): Protocol for a prospective, nonrandomized implementation trial. Am Heart J. Published 25 June 2023. doi:10.
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