Heart failure & cardiomyopathies
Increased Risk of Myocardial Infarction, Heart Failure, and Atrial Fibrillation After Spinal Cord Injury
Authors' conclusion
SCI survivors at all levels were at significantly greater risk for heart disease than non-SCI controls, particularly those with severe disability.
Study context
- Population
- Spinal cord injury survivors and age- and sex-matched non-SCI controls, followed from index date until 2019
- Exposure
- Spinal cord injury (SCI) survivors vs matched non-SCI controls
- SCI survivorsn = 5,083
- Outcome
- Incident MI, HF and AF
- Follow-up
- From index date until 2019
Methodological details1:3 age- and sex-matched
- 1:3 age- and sex-matched
Main finding
As reported in the abstract
SCI survivors vs ControlsAdjusted hazard ratio (95% CI)
MI
2.41(1.93–3.00)
HF
2.24(1.95–2.56)
AF
1.84(1.49–2.28)
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| MI, HF and AF in SCI survivors with severe disability (subgroup)SCI survivors with severe disabilityvs ControlsMI | 3.74 (2.43–5.76) | |
| MI, HF and AF in SCI survivors with severe disability (subgroup)SCI survivors with severe disabilityvs ControlsHF | 3.96 (3.05–5.14) | |
| MI, HF and AF in SCI survivors with severe disability (subgroup)SCI survivors with severe disabilityvs ControlsAF | 3.32 (2.18–5.05) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
- Myocardial infarction (MI), heart failure (HF) and atrial fibrillation (AF) in SCI survivors with severe disability (subgroup): disability = registered in the National Disability Registry within 1 year from index date
Heart disease by SCI level (subgroup)
- Cervical and lumbar SCI: increased risk regardless of disability, slightly higher with disability
- Thoracic SCI with disability: significantly increased risk vs matched controls
Original publication
Increased Risk of Myocardial Infarction, Heart Failure, and Atrial Fibrillation After Spinal Cord Injury. J Am Coll Cardiol. Published 20 February 2024. doi:10.
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