Heart failure & cardiomyopathiesCohort study
Hypertensive Disorders of Pregnancy and Long-Term Risk of Dilated Cardiomyopathy
- Population-based cohort study
- linked electronic health records
- 5:1 unexposed sampling
Authors' conclusion
Patients with hypertensive disorders of pregnancy had a greater risk of developing dilated cardiomyopathy. Older maternal age and postpartum hypertension were associated with higher risk of dilated cardiomyopathy after a hypertensive disorder of pregnancy.
Study context
- Population
- First pregnancies in England, index date January 1997 to December 2018, followed up until July 2023
- Participants
- 14,083 vs 70,415
- Exposure
- HDP vs normotensive first pregnancy
- HDPn = 14,083
- Normotensiven = 70,415reference
- Outcome
- Dilated cardiomyopathy
Main finding
As reported in the abstract
HDP vs NormotensiveAdjusted hazard ratio (95% CI)P value
adjusted for maternal age
1.93(1.33–2.81)
P = 0.001fully adjusted
1.55(1.04–2.31)
P = 0.03Observational data: associations, not effects.
Further findings
Time to DCM post partum
| Outcome | adjusted HR (95% CI) | P value | |
|---|---|---|---|
| DCM by HDP severity (dose response) — Preeclampsia vs Normotensive | 1.85 (1.24–2.76) | P = 0.002 | |
| DCM by HDP severity (dose response) — Severe preeclampsia vs Normotensive | 4.29 (2.32–7.96) | P < 0.001 | |
| Independent risk factors for DCM — Maternal age (per year) | 1.06 (1.03–1.08) | P < 0.001 | |
| Independent risk factors for DCM — Postpartum incident hypertension vs Normotensive | 1.68 (1.16–2.42) | P = 0.006 | |
| 0.10.31310Adjusted hazard ratio (log scale) |
Original publication
Hypertensive Disorders of Pregnancy and Long-Term Risk of Dilated Cardiomyopathy. JAMA Cardiol. Published 1 May 2025. doi:10.1001/jamacardio.2025.0328
Summarised from the published abstract; every number is checked against it