Increasing Extracellular Volume Fraction on Coronary CTA in Patients With Coronary Microvascular Dysfunction
Main finding · CMD, multivariable logistic regressionResult — go to the resultOdds ratio 10.50 95% CI 2.34–47.40Authors' conclusion
In patients with ANOCA with CMD, ECV was significantly elevated, alongside a higher prevalence of DD.
Study context
- Population
- Patients with ANOCA undergoing coronary computed tomography angiography (CCTA) with ECV protocol and invasive functional testing; excluded significant epicardial stenosis, prior revascularization, known MI or HF
- Participants
- 57 patients
- Exposure
- Coronary microvascular dysfunction (CMD) vs no CMD
- CMDn = 26
- Outcome
- Association between CCTA-derived ECV and CMD
Methodological detailssingle-centre
- Single-centre
Main finding
CMD, multivariable logistic regression
Odds ratio
10.50
95% CI 2.34–47.40
P = 0.002
CMD vs no CMD (CCTA-derived ECV)
OR 10.50 (95% CI 2.34–47.40); P = 0.002
As reported in the abstract
- CMD prevalence
- 26 (45.6%)
Observational data: associations, not effects.
Further findings
Diastolic dysfunction (DD) as independent predictor of CMD
| Comparison | OR (95% CI) | P value | |
|---|---|---|---|
| DD | 17.90 (2.53–127.00) | P = 0.004 | |
| 0.050.21520Odds ratio (log scale) |
| Outcome | AUC | P value |
|---|---|---|
| Discrimination for CMD: clinical model incl. DD vs + elevated ECV | 0.854 vs 0.742 | P = 0.019 |
Original publication
Increasing Extracellular Volume Fraction on Coronary CTA in Patients With Coronary Microvascular Dysfunction. Circ Cardiovasc Imaging. Published 30 September 2025. doi:10.
Summarised from the published abstract; every number is checked against it