Heart failure & cardiomyopathies
Incremental Value of C-Reactive Protein to the MEESSI Acute Heart Failure Risk Score
Authors' conclusion
Quantifying inflammation using CRP concentration provided incremental value in AHF risk stratification using the established MEESSI model.
Study context
- Population
- Patients with centrally adjudicated acute heart failure (AHF) (BASEL V)validation cohort n = 575
- Participants
- 1,208 patients
- Comparison
- Extended MEESSI model vs recalibrated MEESSI model
- Outcome
- Prognostic accuracy for 30-day mortality (c-statistic)
- Follow-up
- 30 days
Methodological detailsprospective multicentre cohort with external validation, central adjudication, independent retrospective single-centre validation cohort
- Prospective multicentre cohort with external validation
- Central adjudication
- Independent retrospective single-centre validation cohort
Performance
As reported in the abstract
30-day mortality, c-statistic
| Test or model | C-statistic |
|---|---|
| Extended MEESSI | 0.83 (95% CI 0.79-0.87) |
| Recalibrated MEESSI | 0.79 (95% CI 0.75-0.83) |
C-statistic
Extended MEESSI0.83 (95% CI 0.79-0.87)
Recalibrated MEESSI0.79 (95% CI 0.75-0.83)
- Extended MEESSI vs Recalibrated MEESSI: P = 0.013
Further findings
Patients stratified into lowest risk group
- Calibration of extended model
- 1.00 (95% CI 0.81-1.19) · Calibration slope · Calibration intercept 0.0 (95% CI −0.22 to 0.22)
Independent validation cohort
- Results confirmed in the independent validation cohort (n = 575)
Original publication
Incremental Value of C-Reactive Protein to the MEESSI Acute Heart Failure Risk Score. Eur J Heart Fail. Published 23 June 2024. doi:10.
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