Heart failure & cardiomyopathies
C-Reactive Protein and Risk of Incident Heart Failure in Patients With Cardiovascular Disease
Authors' conclusion
In patients with established CVD, CRP is an independent risk marker of incident HF.
Study context
- Population
- Patients with established cardiovascular disease (CVD) without prevalent heart failure (HF) (UCC-SMART cohort)
- Participants
- 8,089 patients
- Exposure
- Higher vs lower baseline C-reactive protein (CRP)
- Outcome
- Incident HF (first hospitalization for HF)
- Follow-up
- Median 9.7 years (IQR 5.4-14.1 years)
Main finding
As reported in the abstract
Incident HF · median follow-up 9.7 years
Hazard ratio (95% CI)
CRP per 1 mg/L
1.10(1.07–1.13)
Last CRP quartilevs First CRP quartile
2.22(1.76–2.79)
- Incident HF cases
- 810
- Incidence rate
- 1.01/100 person-years
Observational data: associations, not effects.
Further findings
Incident HF by EF type (CRP association)
| HR (95% CI) | ||
|---|---|---|
| HF with reducedHFrEF | 1.09 (1.04–1.14) | |
| Preserved ejection fractionHFpEF | 1.12 (1.07–1.18) | |
| 0.512Hazard ratio (log scale) |
- Incident HF by EF type (CRP association): P for difference = 0.137
Sensitivity analyses
- Additional adjustment for medication use and interim MI did not attenuate the association; consistent beyond 15 years after CRP measurement
Original publication
C-Reactive Protein and Risk of Incident Heart Failure in Patients With Cardiovascular Disease. J Am Coll Cardiol. Published 1 August 2023. doi:10.
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