Heart failure & cardiomyopathies
Indexing cardiac volumes for peak oxygen uptake to improve differentiation of physiological and pathological remodeling: from elite athletes to heart failure patients
Authors' conclusion
Indexing LVEDV to VO2peak improves the ability to differentiate physiological and pathological enlargement.
Study context
- Population
- Healthy adults, HF patients and endurance athletes
- Participants
- 1,190 / 61 / 71
- Exposure
- Indexing left ventricular end-diastolic volume (LVEDV) and LAVmax by absolute VO2peak vs fat-free mass (FFM) vs body surface area (BSA)
- Healthy adultsn = 1,190
- Heart failuren = 61
- Endurance athletesn = 71
- Outcome
- Association of LVEDV and LAVmax with absolute VO2peak and FFM vs BSA; classification to normalcy/pathology by each indexing method
Main finding
As reported in the abstract
Variance in LVEDV explained (healthy adults)
- Absolute VO2peak
- 52%
- BSA
- 32%
- FFM
- 44%
- Athletes classified to pathology by BSA reclassified to normalcy by VO2peak indexing
- 17 of 18 (P < 0.001)
- HF patients reclassified to pathology by VO2peak indexing
- 39-95% (P < 0.001)
Observational data: associations, not effects.
Further findings
Variance in LAVmax explained
- All indexing methods explained below 20% in univariate models
- <20%
Original publication
Indexing cardiac volumes for peak oxygen uptake to improve differentiation of physiological and pathological remodeling: from elite athletes to heart failure patients. Eur Heart J Cardiovasc Imaging. Published 19 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →