Heart failure & cardiomyopathies
Incremental significance of myocardial oedema for prognosis in hypertrophic cardiomyopathy
Authors' conclusion
Patients with HCM with LGE(+) and higher T2 had worse prognosis than those with LGE(+) and lower T2.
Study context
- Population
- Patients with hypertrophic cardiomyopathy (HCM) who underwent CMR, enrolled 2011–2020
- Exposure
- HCM patients with vs without CV events; LGE(+) with T2 max ≥44.9 ms vs lower T2
- Outcome
- Composite of:
- CV death
- Appropriate ICD discharge
- Follow-up
- Median 36 months (IQR 24-60 months)
Main finding
As reported in the abstract
median follow-up 36 months
- Patients with CV events
- 55 (8.2%)
- Higher T2 max, T2 min and T2 global in patients with events vs event-free
- all P < 0.001
- LGE(+) and T2 max ≥44.9 ms: higher risk of CV events
- P < 0.001
- T2 max, T2 min, T2 global prognostic on multivariate Cox regression
- all P < 0.001
- T2 max / T2 min C-index
- 0.825, 0.814
- T2 max / T2 min net reclassification index
- 0.612, 0.536, both P < 0.001
- T2 max / T2 min integrative discrimination index
- 0.029, 0.029, both P < 0.05
Observational data: associations, not effects.
Further findings
Incremental predictive performance of T2 max / T2 min over established risk factors incl. extensive LGE
- C-index (T2 max, T2 min)
- 0.825, 0.814
- Net reclassification index (T2 max, T2 min)
- 0.612, 0.536, both P < 0.001
- Integrative discrimination index (T2 max, T2 min)
- 0.029, 0.029, both P < 0.05
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Incremental significance of myocardial oedema for prognosis in hypertrophic cardiomyopathy. Eur Heart J Cardiovasc Imaging. Published 19 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →