Acute cardiac care & resuscitation

Treatment Time Limit for Successful Weaning from Veno-Arterial Extracorporeal Membrane Oxygenation in Cardiogenic Shock

ESC Heart FailPublished Retrospective cohort study

Main finding · Successful weaning from VA-ECMO (decannulation and survival to discharge)Result — go to the resultOdds ratio 0.813 95% CI 0.679–0.914

Authors' conclusion

Long support duration of VA-ECMO was significantly associated with a low rate of successful weaning in patients with cardiogenic shock.

Study context

Population
Patients with cardiogenic shock treated with veno-arterial extracorporeal membrane oxygenation (VA-ECMO) (OHCA excluded), January 2013 to June 2023
Participants
100 patients
Exposure
VA-ECMO support duration: ≤7 days vs 8-14 days vs ≥15 days
  • Group An = 50
  • Group Bn = 25
  • Group Cn = 25
Outcome
Successful weaning from VA-ECMO (decannulation and survival to discharge)
Methodological detailssingle-centre, consecutive patients
  • Single-centre
  • Consecutive patients

Main finding

As reported in the abstract

Odds ratio

0.813

95% CI 0.679–0.914

P = 0.025

Events by group

Group C

16%

4 of 25

Support duration (per 3 days)
OR 0.813 (95% CI 0.679–0.914); P = 0.025

Per 3 days, as printed

Weaning success across Groups A, B, C
P = 0.002
Overall successfully weaned
43 (43%)

Observational data: associations, not effects.

Further findings

VA-ECMO support duration, successful vs unsuccessful decannulation

VA-ECMO support duration, successful vs unsuccessful decannulation — Significantly longer support duration without successful decannulation
P = 0.004

Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.

Original publication

Treatment Time Limit for Successful Weaning from Veno-Arterial Extracorporeal Membrane Oxygenation in Cardiogenic Shock. ESC Heart Fail. Published 11 July 2024. doi:10.1002/ehf2.14931

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