Inflammation, Cholesterol, Lipoprotein(a), and 30-Year Cardiovascular Outcomes in Women
Authors' conclusion
A single combined measure of high-sensitivity CRP, LDL cholesterol, and lipoprotein(a) levels among initially healthy U.S. women was predictive of incident cardiovascular events during a 30-year period.
Study context
- Population
- Initially healthy US women (Women's Health Study), mean age 54.7 years3,662 first MACE
- Participants
- 27,939 women
- Exposure
- Top vs bottom quintile of baseline hs-CRP, low-density lipoprotein (LDL) cholesterol and lipoprotein(a)
- Outcome
- First MACE:
- MI
- Coronary revascularization
- Stroke
- CV death
- Follow-up
- 30 years
Main finding
As reported in the abstract
Top quintile vs Bottom quintileHazard ratio (95% CI)
High-sensitivity CRP
1.70(1.52–1.90)
LDL cholesterol
1.36(1.23–1.52)
Lipoprotein(a)
1.33(1.21–1.47)
Observational data: associations, not effects.
Further findings
CHD and stroke
- Consistent with primary end point
Combined biomarkers
- Each biomarker contributed independently; greatest risk spread with all three combined
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Inflammation, Cholesterol, Lipoprotein(a), and 30-Year Cardiovascular Outcomes in Women. N Engl J Med. Published 31 August 2024. doi:10.
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