Unidirectional association of clonal hematopoiesis with atherosclerosis development
Authors' conclusion
These findings indicate that clonal hematopoiesis unidirectionally promotes atherosclerosis
Study context
- Population
- Healthy middle-aged individuals
- Exposure
- CH-related mutation vs none; atherosclerosis vs none
- Outcome
- Interplay between clonal hematopoiesis and atherosclerosis
- Follow-up
- 6-year period
Methodological detailslongitudinal, High-sensitivity DNA sequencing in blood and noninvasive vascular imaging
- Longitudinal
- High-sensitivity DNA sequencing in blood and noninvasive vascular imaging
Main finding
As reported in the abstract
6-year period
- CH-related mutation confers increased risk of de novo femoral atherosclerosis
- Neither presence nor extent of atherosclerosis affects mutant cell expansion
Observational data: associations, not effects.
Original publication
Unidirectional association of clonal hematopoiesis with atherosclerosis development. Nat Med. Published 30 August 2024. doi:10.
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