Acute cardiac care & resuscitation
Inflammatory response by 48 h after admission and mortality in patients with acute myocardial infarction complicated by cardiogenic shock
Main finding · 30-day all-cause mortalityResult — go to the resultHazard ratio 2.32 95% CI 1.59–3.39Authors' conclusion
Cardiogenic shock induces an acute inflammatory response, the severity of which is associated with mortality.
Study context
- Population
- Patients with acute MI complicated by cardiogenic shock (AMICS), alive at 48 h with C-reactive protein (CRP) and leucocyte measurement at 48 ± 12 h, 2010–20171,111 analysed
- Participants
- 1,716 patients
- Exposure
- Inflammatory response quartiles
- Outcome
- All-cause mortality
- Follow-up
- 30 days
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
30-day all-cause mortality
Hazard ratio
2.32
95% CI 1.59–3.39
P < 0.001
By group
Q4vs Q1
HR 2.32 (95% CI 1.59–3.39); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Mortality in AMICS with OHCA (subgroup)Multivariable-adjusted | 3.37 (2.02–4.64) | P < 0.001 | |
| 0.20.5125Hazard ratio (log scale) |
CRP and leucocyte count at 48 h (whole cohort)
- Median CRP 145 mg/dL (IQR 96-211)
- 145
- Median leucocyte count 12.6 × 10-9/L (IQR 10.1-16.4)
Baseline characteristics of Q4 · at diagnosis
- Q4 had lower median LVEF and higher lactate at diagnosis
Original publication
Inflammatory response by 48 h after admission and mortality in patients with acute myocardial infarction complicated by cardiogenic shock. Eur Heart J Acute Cardiovasc Care. Published 28 February 2023. doi:10.
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