Arrhythmias & electrophysiology
Worldwide Experience With an Irrigated Needle Catheter for Ablation of Refractory Ventricular Arrhythmias: Final Report
Authors' conclusion
INA achieves improved arrhythmia control in 78% of patients with PVCs and avoids hospitalization in 69% of patients with VT refractory to standard ablation at 6-month follow-up.
Study context
- Population
- Patients with recurrent sustained monomorphic ventricular tachycardia (VT) or high-density premature ventricular contractions (PVCs) despite radiofrequency ablation, treated with irrigated needle ablation (INA), 4 centres
- Participants
- 111 patients4 centres
- Exposure
- VT vs PVC
- VTn = 72
- PVCn = 37
- Outcome
- 70% decrease in VT frequency or PVC burden decrease to <5,000/24 h
- Follow-up
- 6 months
Methodological detailsmulticentre, single-group
- Multicentre
- Single-group
Main finding
As reported in the abstract
| Group | Value | PVCs reduced to <5,000/day | Targeted PVCs acutely abolished | Freedom from hospitalization | Improvement or abolition of VT |
|---|---|---|---|---|---|
| PVC | 78% | 29 patients (78%) | 33 of 37 patients (89%) | ||
| VT | 69% | 50 of 72 patients (69%) | 47% |
Value
PVC78%
VT69%
PVCs reduced to <5,000/day
PVC29 patients (78%)
VT— not stated in the abstract
Targeted PVCs acutely abolished
PVC33 of 37 patients (89%)
VT— not stated in the abstract
Freedom from hospitalization
PVC— not stated in the abstract
VT50 of 72 patients (69%)
Improvement or abolition of VT
PVC— not stated in the abstract
VT47%
Observational data: associations, not effects.
Further findings
Median
| Outcome | VT | PVC | P value |
|---|---|---|---|
| Number of INA applications | 12 (IQR 7–19) | 7 (IQR 5–15) | P < 0.01 |
Additional endocardial standard radiofrequency ablation required after INA
- Additional endocardial ablation required
- 23%
Deaths · 6-month follow-up
- Deaths
- 5
- Procedure-related deaths
- 0
Safety
Adverse events
- Pericardial effusions
- 4 (3.5%)
- Atrioventricular block (anticipated)
- 3 (2.6%)
- HF exacerbations
- 3 (2.6%)
Original publication
Worldwide Experience With an Irrigated Needle Catheter for Ablation of Refractory Ventricular Arrhythmias: Final Report. JACC Clin Electrophysiol. Published 19 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →