Influence of Subclinical Atherosclerosis Burden and Progression on Mortality
Authors' conclusion
Subclinical atherosclerosis burden (cPB and CAC) in asymptomatic individuals was independently associated with all-cause mortality. Moreover, atherosclerosis progression was independently associated with all-cause mortality.
Study context
- Population
- Asymptomatic US adults (mean age 68.9 years, 56.7% female), BioImage study, enrolled 2008–2009732 with follow-up ultrasound
- Participants
- 5,716 adults
- Outcome
- All-cause mortality
- Follow-up
- Median 12.4 years'
Main finding
As reported in the abstract
median 12.4 years
Estimate (95% CI)P value
cPBbaseline cPB, per-tertile increase
fully adjusted trend HR 1.23(1.16–1.32)
P < 0.001CAC scorebaseline CAC score, per-tertile increase
HR 1.15(1.08–1.23)
P < 0.001Per-tertile increase, as printed
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| cPB progression and all-cause mortality · follow-up ultrasound median 8.9 years after baselineAdjusted for CV risk factors and baseline cPB | 1.03 (1.01–1.04) | P = 0.01 | |
| 0.512Hazard ratio (log scale) |
- Carotid plaque burden (cPB) progression and all-cause mortality: 732 participants with second ultrasound
cPB progression and all-cause mortality · follow-up ultrasound median 8.9 years after baseline
- Median cPB progressed from 29.2 to 91.3 mm³
Original publication
Influence of Subclinical Atherosclerosis Burden and Progression on Mortality. J Am Coll Cardiol. Published 8 October 2024. doi:10.
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