Antibodies Against Phosphorylcholine in Prediction of Cardiovascular Disease Among Women: A Population-Based Prospective Cohort Study
Main finding · Incident CVD, IHD, MI, ischemic strokeResult — go to the resultHazard ratio 0.27 95% CI 0.11–0.68Authors' conclusion
IgM anti-PC may play an active role in inhibition of CVD development in women, especially MI.
Study context
- Population
- Women aged 66 ± 6 years, population-based Swedish Mammography Cohort
- Participants
- 932 women13,033 person-years
- Exposure
- IgM anti-PC tertiles
- Outcome
- Incident CVD (any first CVD, IHD, MI, ischemic stroke)
- Follow-up
- 16 years
Methodological detailspopulation-based
- Population-based
Main finding
Incident CVD, IHD, MI, ischemic stroke
Hazard ratio
0.27
95% CI 0.11–0.68
P < 0.01 for trend
Highest tertilevs Lowest tertile
HR 0.27 (95% CI 0.11–0.68); P for trend < 0.01
As reported in the abstract
- Composite cardiovascular disease (CVD) cases
- 113
- Ischemic heart disease (IHD) cases
- 69
- Myocardial infarction (MI) cases
- 44
- Ischemic stroke cases
- 50
Observational data: associations, not effects.
Original publication
Antibodies Against Phosphorylcholine in Prediction of Cardiovascular Disease Among Women: A Population-Based Prospective Cohort Study. JACC Adv. Published 2 October 2024. doi:10.
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