Heart failure & cardiomyopathies
Influencing and Prognostic Factors of End-Stage Hypertrophic Cardiomyopathy
Authors' conclusion
The influencing factors for ES-HCM included the age at first symptom onset, NYHA class, heart rate, QRS duration, LVEDD, LAD, and MLVWT. Both NYHA class and heart rate were related to the prognosis of ES-HCM.
Study context
- Population
- Patients with HCM hospitalized for the first time at Fujian Medical University Union Hospital, 2013–20211,282 HCM patients screened
- Participants
- 250 patients
- Comparison
- End-stage hypertrophic cardiomyopathy (ES-HCM) vs HCM with left ventricular ejection fraction (LVEF) ≥ 50%
- ES-HCMn = 50
- HCM with LVEF ≥ 50%n = 200reference
- Outcome
- Influencing factors of ES-HCM (multivariate logistic regression)
Methodological detailssingle-centre, matched 4:1 on age and sex
- Single-centre
- Matched 4:1 on age and sex
Main finding
As reported in the abstract
Factors associated with ES-HCM (multivariate logistic regression)
ES-HCM vs HCM with LVEF ≥ 50%Odds ratio (95% CI)P value
Age at first symptom onset
0.95(0.90–1.00)
P = 0.042NYHA class
7.73(2.93–20.41)
P < 0.001Heart rate
1.07(1.02–1.12)
P = 0.003QRS duration
1.03(1.00–1.05)
P = 0.020LVEDD
1.15(1.04–1.28)
P = 0.006LAD
1.13(1.03–1.24)
P = 0.012MLVWT
0.80(0.68–0.93)
P = 0.005Observational data: associations, not effects.
Further findings
All-cause death · median follow-up 2.8 (1.4-5.4) years
P < 0.001
CV death · median follow-up 2.8 (1.4-5.4) years
P < 0.001
Heart transplantation or all-cause mortality within ES-HCM (univariate)
- New York Heart Association (NYHA) class associated with higher likelihood and earlier occurrence
- P < 0.001
- Heart rate associated with higher likelihood and earlier occurrence
- P = 0.017
- Univariate analyses
Original publication
Influencing and Prognostic Factors of End-Stage Hypertrophic Cardiomyopathy. ESC Heart Fail. Published 2 August 2024. doi:10.
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