Heart failure & cardiomyopathies
Prognostic Impact of Late Gadolinium Enhancement (LGE) Granularity Using CMR in End‑Stage Hypertrophic Cardiomyopathy
Authors' conclusion
In this large multicenter cohort of patients with end-stage HCM, the LGE granularity model integrating LGE extent, location, and pattern provided strong and independent prognostic value.
Study context
- Population
- Patients with end-stage hypertrophic cardiomyopathy (HCM) (left ventricular ejection fraction <50%) referred for cardiovascular magnetic resonance assessment, 2008–2024with end-stage HCM, among 2873 patients with HCM screened
- Participants
- 691 patients
- Exposure
- LGE granularity model and mortality
- LGEn = 259
- Outcome
- All-cause mortality
- Follow-up
- Median 9 years (interquartile range, 6-11)
Methodological details3 French tertiary university hospitals, multicenter
- 3 French tertiary university hospitals
- Multicenter
Main finding
As reported in the abstract
Hazard ratio (95% CI)P value
LGEafter adjustment for classical prognostic factors
1.52(1.07–2.18)
P = 0.02LGE extentadjusted
2.85(1.03–7.85)
P = 0.02Septal locationadjusted
1.73(1.10–2.73)
P < 0.001Midwall patternadjusted
4.15(1.79–9.61)
P < 0.001- Patients died
- 226 (33%)
Observational data: associations, not effects.
Original publication
Prognostic Impact of LGE Granularity Using CMR in End‑Stage Hypertrophic Cardiomyopathy. Circ Cardiovasc Imaging. Published 22 May 2026. doi:10.
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