Initial statin dose after myocardial infarction and long-term cardiovascular outcomes
Authors' conclusion
Higher initial statin dose after MI is dose-dependently associated with better long-term cardiovascular outcomes.
Study context
- Population
- Consecutive myocardial infarction (MI) patients in Finland using statins early after index eventmedian follow-up 4.9 years
- Participants
- 72,401 patients
- Exposure
- High- vs moderate- vs low-dose initial statin after MI
- Outcome
- MACCE
- Follow-up
- Within 10 years
Methodological detailsnational registries, multivariable-adjusted, Adjusted for baseline features, comorbidities, revascularisation and other evidence-based medications by multivariable regression
- National registries
- Multivariable-adjusted
- Adjusted for baseline features, comorbidities, revascularisation and other evidence-based medications by multivariable regression
Main finding
As reported in the abstract
Adjusted hazard ratio
0.92
P < 0.0001
High dose vs Moderate dose · NNT 34.1
Adjusted hazard ratio
0.81
P < 0.001
High dose vs Low dose · NNT 13.4
Adjusted hazard ratio
0.88
P < 0.0001
Moderate dose vs Low dose · NNT 23.4
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | P value |
|---|---|---|
| Death, recurrent MI, strokeHigh dose vs Moderate dose · death; NNT 23.6 | adjusted HR 0.87 | P < 0.0001 |
| Death, recurrent MI, strokeHigh dose vs Moderate dose · recurrent MI | adjusted sHR 0.91 | P = 0.0001 |
| Death, recurrent MI, strokeHigh dose vs Moderate dose · stroke | adjusted sHR 0.86 | P < 0.0001 |
Long-term outcomes by subgroup (age, sex, AF, dementia, DM, HF, revascularisation, prior statin, other medications)
- Higher initial statin dose associated with better long-term outcomes in all subgroups
Original publication
Initial statin dose after myocardial infarction and long-term cardiovascular outcomes. Eur Heart J Cardiovasc Pharmacother. Published 16 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →