Heart failure & cardiomyopathies
Inpatient versus outpatient diagnosis of heart failure across the spectrum of ejection fraction: a population cohort study
Main finding · Time to cardiovascular death or hHFResult — go to the resultAdjusted hazard ratio 1.62 CI 1.39–1.89Authors' conclusion
Individuals whose first presentation was a HF hospitalisation had a significantly worse outcome than those who were diagnosed in the community. Among hospitalised individuals, higher use of GDMT was associated with improved outcomes. Our results highlight the importance of improving diagnostic pathways to allow for earlier identification and treatment of HF.
Study context
- Population
- Patients with incident heart failure (HF) diagnosis in Tayside, Scotland, with linked electronic health records and echocardiography data, 2015–2021, and a non-HF comparator group with normal left ventricular functionindividuals identified · HF 4,231 · non-HF comparators 992
- Participants
- 5,223 patients
- Exposure
- Inpatient versus outpatient diagnosis of HF
- Inpatientsn = 2,169
- non-HF comparatorsn = 992
- Outcome
- time to cardiovascular death or hHF
- Follow-up
- Within 12 months of diagnosis
Main finding
As reported in the abstract
Adjusted hazard ratio
1.62
CI 1.39–1.89
P < 0.001
Events by group
Inpatients
809
events
Outpatients
384
events
Inpatientsvs outpatients
adjusted HR 1.62 (CI 1.39–1.89); P < 0.001
- Individuals with HF
- 1193 (28.1%)
- non-HF comparators
- 32 (3.2%)
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted HR (CI) | P value | |
|---|---|---|---|
| Primary outcome in HFrEF patients first diagnosed as inpatients, by GDMT at discharge (≥2 GDMT vs <2 GDMT)303 vs 175 events | 0.72 (0.55–0.94) | P = 0.016 | |
| 0.512Adjusted hazard ratio (log scale) |
Diagnosis setting
- Of the 4231 HF patients, diagnosed as inpatients
- 2169 (51.3%)
Original publication
Inpatient versus outpatient diagnosis of heart failure across the spectrum of ejection fraction: a population cohort study. Heart. Published 29 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →