Insomnia symptoms and incident heart failure: a population-based cohort study
Authors' conclusion
Insomnia symptoms, both cumulatively and individually, are associated with incident HF.
Study context
- Population
- US middle-aged and older adults (age ≥ 50 years) free from heart failure (HF) at baseline in 2002, Health and Retirement Study1,730 incident HF
- Participants
- 12,761 participants
- Exposure
- Insomnia symptoms vs no insomnia symptoms
- Outcome
- Incident HF
- Follow-up
- 16-year follow-up
Methodological detailspopulation-based, marginal structural discrete-time survival analyses
- Population-based
- Marginal structural discrete-time survival analyses
Main finding
As reported in the abstract
Incident HF by number of insomnia symptoms
Each group vs asymptomaticHazard ratio (95% CI)
One symptom
1.22(1.08–1.38)
Two symptoms
1.45(1.21–1.72)
Three symptoms
1.66(1.37–2.02)
Four symptoms
1.80(1.25–2.59)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Incident HF by individual insomnia symptom · 16-year follow-upTrouble initiating sleep vs Asymptomatic | 1.17 (1.01–1.36) | |
| Incident HF by individual insomnia symptom · 16-year follow-upTrouble maintaining sleep vs Asymptomatic | 1.14 (1.01–1.28) | |
| Incident HF by individual insomnia symptom · 16-year follow-upEarly-morning awakening vs Asymptomatic | 1.20 (1.02–1.43) | |
| Incident HF by individual insomnia symptom · 16-year follow-upNon-restorative sleep vs Asymptomatic | 1.25 (1.06–1.46) | |
| 0.512Hazard ratio (log scale) |
≥1 insomnia symptom at baseline
- Respondents reporting at least one insomnia symptom
- 38.4%
Original publication
Insomnia symptoms and incident heart failure: a population-based cohort study. Eur Heart J. Published 15 August 2021. doi:10.
Summarised from the published abstract; every number is checked against it