Heart failure & cardiomyopathies
Integrated Trajectories of Systolic and Diastolic Function Differentially Associate with Risk for Heart Failure with Preserved and Reduced Ejection Fraction and Proteomic Profiles
Authors' conclusion
Bayesian non-parametric modelling identifies cardiac function trajectories differentially associated with HFpEF and HFrEF
Study context
- Population
- Older adults: Jackson Heart Study participants with ≥2 echocardiograms (derivation) and Atherosclerosis Risk in Communities (ARIC) participants (testing cohort, age 75 ± 5 years)747 JHS derivation
- Exposure
- Predicted left ventricular ejection fraction (LVEF) and E/A ratio trajectories vs pink trajectory
- Outcome
- Incident HFpEF and HFrEF by predicted trajectory
Methodological detailsBayesian non-parametric trajectory modelling, external testing cohort, Mendelian randomization
- Bayesian non-parametric trajectory modelling
- External testing cohort
- Mendelian randomization
Main finding
As reported in the abstract
Incident HFpEF and HFrEF vs pink (testing cohort)
- Red and dark green associated with HFrEF alone
- Blue associated with HFpEF alone
- Orange associated with both HFrEF and HFpEF
Observational data: associations, not effects.
Further findings
Risk prediction
- Trajectory membership provided incremental value in predicting HF and HFpEF
Proteomics and Mendelian randomization
- Trajectory-associated proteins with potential causal effects on LVEF and volume
- 13
- 4877 plasma proteins (SOMAscan)
Original publication
Integrated Trajectories of Systolic and Diastolic Function Differentially Associate with Risk for Heart Failure with Preserved and Reduced Ejection Fraction and Proteomic Profiles. Eur J Heart Fail. Published 2 September 2025. doi:10.
Summarised from the published abstract; every number is checked against it