Heart failure & cardiomyopathies
Integrating pulmonary function testing with cardiopulmonary exercise testing for enhanced stratification in hypertrophic cardiomyopathy
Authors' conclusion
PFT metrics strongly correlate with CPET parameters in HCM, suggesting that PFT could complement CPET for a more comprehensive assessment of exercise capacity and patient stratification.
Study context
- Population
- Clinically stable patients with hypertrophic cardiomyopathy (HCM)clinically stable patients with HCM who underwent pulmonary function testing (PFT) and cardiopulmonary exercise testing (CPET)
- Participants
- 102 patients
- Exposure
- Relationships between PFT (forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV ₁ )) and CPET variables, adjusting for confounders
- Outcome
- Lung function
Main finding
As reported in the abstract
Mean FVC
90.7%
FEV 1
92.5%
Observational data: associations, not effects.
Further findings
Correlation of PFT with peak VO ₂
- FVC
- r=0.649, p<0.001
- FEV ₁
- r=0.691, p<0.001
- Spearman’s correlation
Correlation of PFT with peak ventilation
- FVC
- r=0.682, p<0.001
- FEV ₁
- r=0.688, p<0.001
- Spearman’s correlation
Independent associations between PFT and CPET performance (regression analysis)
- Regression analysis confirmed independent associations
- all p<0.001
- Multiple linear regression, adjusting for confounders
Original publication
Integrating pulmonary function testing with cardiopulmonary exercise testing for enhanced stratification in hypertrophic cardiomyopathy. Heart. Published 16 April 2025. doi:10.
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