Heart failure & cardiomyopathies
Signs of Congestion, Quality of Life and Short-Term Rehospitalization in Patients with Heart Failure
Authors' conclusion
Peripheral oedema and orthopnoea showed the strongest association with QoL in patients admitted for HF. JVP had the strongest association with the risk of 60 day rehospitalization. Clinically, it is important to distinguish between individual signs due to the discrepancy of their impact on outcome.
Study context
- Population
- Heart failure (HF) patients hospitalized for worsening HFHF patients hospitalized for worsening HF
- Participants
- 1,551 patients
- Exposure
- Associations of signs of HF to quality of life (QoL) and 60 day HF rehospitalization
- Outcome
- QoL (KCCQ-23), association with peripheral oedema and orthopnoea
Methodological detailsexternally validated in a similar independent cohort
- Externally validated in a similar independent cohort
Main finding
As reported in the abstract
Peripheral oedema, standardized beta
−0.210
P < 0.001
Orthopnoea, standardized beta
−0.206
P < 0.001
Observational data: associations, not effects.
Further findings
60 day HF rehospitalization, elevated jugular venous pressure (JVP)
| HR (CI) | P value | ||
|---|---|---|---|
| Elevated jugular venous pressure (JVP) | 1.64 (1.03–2.60) | P = 0.038 | |
| 0.20.5125Hazard ratio (log scale) |
| Outcome | HR (per 5-unit KCCQ decrease) (CI) | P value | |
|---|---|---|---|
| 60 day HF rehospitalization, QoL | 1.09 (1.04–1.14) | P < 0.001 | |
| 0.512Hazard ratio (log scale) |
- 60 day HF rehospitalization, elevated JVP: only multivariable adjusted congestive sign associated with higher risk
- 60 day HF rehospitalization, QoL: The presence or absence of signs of congestion did not modify the association
Characteristics of patients with worse QoL
- Patients with worse QoL were older and more often female and had more comorbidities and signs of HF
Original publication
Signs of Congestion, Quality of Life and Short-Term Rehospitalization in Patients with Heart Failure. ESC Heart Fail. Published 16 April 2025. doi:10.
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