Prevention & lipidsRandomised controlled trial
Intensive Low-density Lipoprotein (LDL) Cholesterol Targeting in Atherosclerotic Cardiovascular Disease
- Randomised controlled trial
- open-label
- superiority
- Median follow-up 3.0 years
Authors' conclusion
Among patients with atherosclerotic cardiovascular disease, targeting an LDL cholesterol level of less than 55 mg per deciliter resulted in a lower risk of cardiovascular events at 3 years than targeting a level of less than 70 mg per deciliter.
Study context
- Population
- Patients with atherosclerotic CVD, South Korea
- Participants
- 3,048 patients
- Comparison
- Intensive LDL-C targeting vs conventional targeting
- Intensive targetingn = 1,526
- Conventional targetingn = 1,522reference
- Primary endpoint
- CV death, nonfatal MI, nonfatal stroke, any revascularization or hospitalization for unstable angina
- Follow-up
- 3 years
Primary result
As reported in the abstract
Hazard ratio
0.67
95% CI 0.52–0.86
P = 0.002
Events by treatment group
Intensive targeting vs Conventional targeting
HR 0.67 (95% CI 0.52–0.86); P = 0.002
Further findings
LDL-C during the trial
Safety
Prespecified safety end points
- Similar in the two groups, except lower incidence of creatinine elevation with intensive targeting
Original publication
Intensive LDL Cholesterol Targeting in Atherosclerotic Cardiovascular Disease. N Engl J Med. Published 28 March 2026. doi:10.1056/nejmoa2600283
Summarised from the published abstract; every number is checked against it