Inter-ethnic differences in valve morphology, valvular dysfunction, and aortopathy between Asian and European patients with bicuspid aortic valve
Authors' conclusion
This large multicentre registry reports for the first time that Asians with BAV showed more frequently type 1 BAV (with fusion between right and non-coronary cusp) and have larger aortic dimensions than Europeans.
Study context
- Population
- Patients with bicuspid aortic valve (BAV)
- Participants
- 1,427 patients
- Exposure
- Asian vs European patients with BAV
- Asiansn = 633
- Europeansn = 794reference
- Outcome
- Differences in valve morphology and function and aortic root dimensions on transthoracic echocardiography
Methodological detailsmulticentre registry
- Multicentre registry
Main finding
As reported in the abstract
Asians
- Type 1 BAV with raphe between right and non-coronary cusps
- 19.7%
- Type 0 BAV
- 6.8%
- Moderate and severe AR
- 26.8%
Europeans
- Type 1 BAV with raphe between right and non-coronary cusps
- 13.6%
- Type 0 BAV
- 14.5%
- Moderate and severe AR
- 44.2%
Type 1 BAV with raphe between right and non-coronary cusps
Asians19.7%
Europeans13.6%
Type 0 BAV
Asians6.8%
Europeans14.5%
Moderate and severe AR
Asians26.8%
Europeans44.2%
Asians vs EuropeansMean difference, mm/m2 (95% CI)
Aortic annulus, adjusted
1.17(0.96–1.39)
SOV, adjusted
1.86(1.47–2.24)
STJ, adjusted
0.52(0.14–0.90)
AA, adjusted
1.05(0.57–1.52)
Observational data: associations, not effects.
Original publication
Inter-ethnic differences in valve morphology, valvular dysfunction, and aortopathy between Asian and European patients with bicuspid aortic valve. Eur Heart J. Published 6 October 2017. doi:10.
Summarised from the published abstract; every number is checked against it